Peptide-Based Vaccination for Antibody Responses Against HIV
Identifieur interne : 000173 ( France/Analysis ); précédent : 000172; suivant : 000174Peptide-Based Vaccination for Antibody Responses Against HIV
Auteurs : Behazine Combadiere [France] ; Manon Beaujean [France] ; Chloé Chaudesaigues [France] ; Vincent Vieillard [France]Source :
- Vaccines [ 2076-393X ] ; 2019.
English descriptors
Abstract
HIV-1 is responsible for a global pandemic of 35 million people and continues to spread at a rate of >2 million new infections/year. It is widely acknowledged that a protective vaccine would be the most effective means to reduce HIV-1 spread and ultimately eliminate the pandemic, whereas a therapeutic vaccine might help to mitigate the clinical course of the disease and to contribute to virus eradication strategies. However, despite more than 30 years of research, we do not have a vaccine capable of protecting against HIV-1 infection or impacting on disease progression. This, in part, denotes the challenge of identifying immunogens and vaccine modalities with a reduced risk of failure in late stage development. However, progress has been made in epitope identification for the induction of broadly neutralizing antibodies. Thus, peptide-based vaccination has become one of the challenges of this decade. While some researchers reconstitute envelope protein conformation and stabilization to conserve the epitope targeted by neutralizing antibodies, others have developed strategies based on peptide-carrier vaccines with a similar goal. Here, we will review the major peptide-carrier based approaches in the vaccine field and their application and recent development in the HIV-1 field.
Url:
DOI: 10.3390/vaccines7030105
Affiliations:
Links toward previous steps (curation, corpus...)
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- to stream Main, to step Exploration: 000247
- to stream France, to step Extraction: 000173
Links to Exploration step
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</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="mix" xml:lang="en"><term>HIV-1</term>
<term>adjuvants</term>
<term>neutralizing antibodies</term>
<term>peptide-conjugate</term>
<term>vaccination</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"> <p>HIV-1 is responsible for a global pandemic of 35 million people and continues to spread at a rate of >2 million new infections/year. It is widely acknowledged that a protective vaccine would be the most effective means to reduce HIV-1 spread and ultimately eliminate the pandemic, whereas a therapeutic vaccine might help to mitigate the clinical course of the disease and to contribute to virus eradication strategies. However, despite more than 30 years of research, we do not have a vaccine capable of protecting against HIV-1 infection or impacting on disease progression. This, in part, denotes the challenge of identifying immunogens and vaccine modalities with a reduced risk of failure in late stage development. However, progress has been made in epitope identification for the induction of broadly neutralizing antibodies. Thus, peptide-based vaccination has become one of the challenges of this decade. While some researchers reconstitute envelope protein conformation and stabilization to conserve the epitope targeted by neutralizing antibodies, others have developed strategies based on peptide-carrier vaccines with a similar goal. Here, we will review the major peptide-carrier based approaches in the vaccine field and their application and recent development in the HIV-1 field.</p>
</div>
</front>
</TEI>
<affiliations><list><country><li>France</li>
</country>
</list>
<tree><country name="France"><noRegion><name sortKey="Combadiere, Behazine" sort="Combadiere, Behazine" uniqKey="Combadiere B" first="Behazine" last="Combadiere">Behazine Combadiere</name>
</noRegion>
<name sortKey="Beaujean, Manon" sort="Beaujean, Manon" uniqKey="Beaujean M" first="Manon" last="Beaujean">Manon Beaujean</name>
<name sortKey="Chaudesaigues, Chloe" sort="Chaudesaigues, Chloe" uniqKey="Chaudesaigues C" first="Chloé" last="Chaudesaigues">Chloé Chaudesaigues</name>
<name sortKey="Vieillard, Vincent" sort="Vieillard, Vincent" uniqKey="Vieillard V" first="Vincent" last="Vieillard">Vincent Vieillard</name>
</country>
</tree>
</affiliations>
</record>
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